Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Infertility in Males01:23

Infertility in Males

522
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
522
Antihypertensive Drugs: Thiazide-Class Diuretics01:15

Antihypertensive Drugs: Thiazide-Class Diuretics

1.6K
Thiazide diuretics are sulfonamide derivatives featuring a benzothiadiazine ring system in their molecular structure. Based on this structure, thiazide diuretics can be categorized into two groups: thiazide-type and thiazide-like diuretics. Thiazide-type diuretics, including hydrochlorothiazide and chlorothiazide, consist of a benzothiadiazine backbone with an attached sulfonamide group. Thiazide-like diuretics, such as chlorthalidone and indapamide, lack the thiazide ring but demonstrate...
1.6K
Spermatogenesis01:41

Spermatogenesis

121.5K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
121.5K
Birth Control Methods01:22

Birth Control Methods

5.8K
Vasectomy is a surgical form of male sterilization that involves severing and sealing the vasa deferentia, preventing sperm from mixing with semen during ejaculation. Because a vasectomy does not impact the testes' ability to produce testosterone, hormone levels, libido, and sexual function generally remain unchanged. While vasectomy is highly effective in preventing pregnancy, with a success rate near 99.85%, rare cases of recanalization (spontaneous reconnection) can occur. Although...
5.8K
Drugs Affecting Neurotransmitter Synthesis01:29

Drugs Affecting Neurotransmitter Synthesis

2.1K
Drugs affecting neurotransmitter synthesis can impact the adrenergic neuron and the synthesis of neurotransmitters. For example, α-methyltyrosine and carbidopa target specific enzymes involved in catecholamine synthesis. α-methyltyrosine inhibits the enzyme tyrosine hydroxylase, which converts tyrosine into dopamine. By blocking this enzyme, α-methyltyrosine reduces dopamine production and other catecholamines. Carbidopa, on the other hand, inhibits the enzyme dopa decarboxylase,...
2.1K
Drugs Affecting Neurotransmitter Release or Uptake01:21

Drugs Affecting Neurotransmitter Release or Uptake

1.5K
Certain drugs can affect how neurotransmitters called catecholamines, are released or taken back up in the adrenergic neuron. They can have different effects on the body's sympathetic transmission. Reserpine, a natural compound found in the Rauwolfia shrub, blocks a transporter called vesicular monoamine transporter (VMAT), which leads to a buildup of catecholamines in the cell and reduces sympathetic transmission. Another drug called guanethidine works in multiple ways, including blocking...
1.5K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Luteinizing hormone supplementation and cumulative live birth rate in assisted reproductive technology cycles among women of advanced reproductive age.

Frontiers in endocrinology·2026
Same author

Atomoxetine hydrochloride impairs human sperm quality and function via disruption of calcium homeostasis and PKC signaling: A combined network pharmacology and in vitro study.

Reproductive toxicology (Elmsford, N.Y.)·2026
Same author

Transfer RNA-derived small RNAs in female reproductive disorders: emerging roles and clinical implications.

Journal of assisted reproduction and genetics·2026
Same author

Programming asphalt-derived carbon microstructures via oxygen-induced precursor restructuring for alkali-ion battery anodes.

Journal of colloid and interface science·2026
Same author

Tuning 4f-2p-3d gradient orbital coupling in perovskite heterointerfaces to optimize Co<sup>2+</sup>/Co<sup>3+</sup> redox cycling for peroxymonosulfate activation.

Journal of colloid and interface science·2026
Same author

Lysine malonylation regulates human sperm motility.

Communications biology·2026

関連する実験動画

Updated: Jan 13, 2026

Medium-throughput Screening Assays for Assessment of Effects on Ca2+-Signaling and Acrosome Reaction in Human Sperm
05:44

Medium-throughput Screening Assays for Assessment of Effects on Ca2+-Signaling and Acrosome Reaction in Human Sperm

Published on: March 1, 2019

8.7K

クロニジンはヒト精子の機能を損なう

Xuchang Liu1, Yanfan Cui2, Ruirui Qian2

  • 1Queen Mary School, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330031, China.

Reproductive toxicology (Elmsford, N.Y.)
|January 10, 2026
PubMed
まとめ
この要約は機械生成です。

クロニジンは精子機能に干渉することにより男性の妊よう性に影響を与えます。低用量では精子を温存しますが、高用量では毒性があり、主要な受精シグナル伝達経路を阻害します。

キーワード:
カルシウムシグナル伝達CatSperチャネルクロニジンミトコンドリア膜電位プロゲステロン精子

さらに関連する動画

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
06:24

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies

Published on: January 10, 2025

1.4K
Recording Electrical Currents across the Plasma Membrane of Mammalian Sperm Cells
09:47

Recording Electrical Currents across the Plasma Membrane of Mammalian Sperm Cells

Published on: February 14, 2021

3.0K

関連する実験動画

Last Updated: Jan 13, 2026

Medium-throughput Screening Assays for Assessment of Effects on Ca2+-Signaling and Acrosome Reaction in Human Sperm
05:44

Medium-throughput Screening Assays for Assessment of Effects on Ca2+-Signaling and Acrosome Reaction in Human Sperm

Published on: March 1, 2019

8.7K
Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
06:24

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies

Published on: January 10, 2025

1.4K
Recording Electrical Currents across the Plasma Membrane of Mammalian Sperm Cells
09:47

Recording Electrical Currents across the Plasma Membrane of Mammalian Sperm Cells

Published on: February 14, 2021

3.0K

科学分野:

  • 生殖生物学; 薬理学; 男性医学

背景:

  • クロニジンは、高血圧およびADHDの一般的な治療薬です。 男性の妊よう性に対するその影響は、ほとんど知られていません。 これらの影響を理解することは、生殖医療にとって重要です。

研究 の 目的:

  • ヒト精子機能に対するクロニジンの影響を調査すること。 プロゲステロン誘発性シグナル伝達経路に対するその効果を分析すること。 男性の妊よう性に影響を与える可能性のあるメカニズムを特定すること。

主な方法:

  • 様々なクロニジン濃度（6.25～200μM）に曝露されたヒト精子。 生存率、運動性（CASA）、カルシウムシグナル伝達、電気生理学、ミトコンドリア電位、ROS、キャパシテーション、およびタンパク質リン酸化を評価しました。 エオジン染色、クロルテトラサイクリン染色、およびウェスタンブロットを使用しました。

主要な成果:

  • クロニジンは二相性の効果を示しました。≤50μMは生存率/運動性を維持しましたが、≥100μMは細胞毒性をもたらしました。 プロゲステロン誘発性のカルシウムシグナル伝達、キャパシテーション、およびアクロソーム反応を強力に阻害しました。 CatSperチャネル活性を部分的に増強し、カルシウム応答の約50%に影響を与えました。

結論:

  • クロニジンは、プロゲステロン媒介性の精子応答を選択的に妨害します。 ベースラインの精子機能を維持しながら、受精シグナル伝達を妨害します。 本研究結果は、in vitroでの男性の妊よう性に影響を与える新たなメカニズムを示唆しており、さらなる臨床調査が必要です。