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Updated: Jan 13, 2026

Mouse Model of Metabolic Dysfunction-Associated Steatotic Liver Disease with Fibrosis

Mouse Model of Metabolic Dysfunction-Associated Steatotic Liver Disease with Fibrosis

Published on: July 18, 2025

代謝機能障害関連脂肪性肝疾患は眼循環に影響を与えるか？

Nihat Aydın¹, Mustafa Capraz², Burcu Akman³

¹Department of Ophthalmology, Amasya University, Sabuncuoğlu Şerefeddin Training and Research Hospital, Amasya, Turkey.

Photodiagnosis and photodynamic therapy

|January 10, 2026

要旨

Purpose:

To evaluate the choroidal thickness (CT), central retinal artery (CRA), ophthalmic artery (OA), internal carotid artery (ICA) and common carotid artery (CCA) hemodynamic parameters and the carotid intima-media thickness (CIMT) in patients with metabolic dysfunction-associated steatotic liver disease (MASLD).

Methods:

This prospective study included 98 MASLD patients and 30 healthy controls. MASLD patients were classified into three stages via liver ultrasonography.

Results:

CT was significantly decreased at all measured points in Stage 2 and Stage 3 MASLD patients versus controls and at subfoveal and nasal (500-1000-1500 µm) points in Stage 3 compared to Stage 1(all p < 0.05). A significant relationship was observed between CT and age, MASLD stage, and GGT levels. OA peak sistolik velocity (PSV), ICA PSV, enddiastolic velocity (EDV), and CCA EDV values were significantly lower in Stage 3 compared to the control group and Stage 1 while the ICA PSV and CCA EDV values were significantly lower in Stage 3 compared to Stage 2 (all p < 0.05). The CCA resistive index (RI) and pulsatile index (PI) were significantly higher in Stage 3 than in the control group and Stage 1 as with the CCA PI value in Stage 3 compared to Stage 2 (p = 0.026, p = 0.035, p = 0.011, p = 0.014, p = 0.022, respectively). CIMT was significantly higher in Stage 3 than in controls (p = 0.005).

Conclusions:

MASLD affects ocular vascular structures and may be associated with an increased risk of ocular pathologies.

キーワード:

脈絡膜厚カラードップラー超音波検査代謝機能障害関連脂肪性肝疾患眼血流光干渉断層計

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Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease

Published on: March 24, 2023

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss

Published on: July 19, 2024

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