健康な成人における笑い運動が眼圧、シュレム管および脈絡網膜パラメータに及ぼす影響

This study investigated the effects of laughter exercise on IOP, anterior and posterior segment parameters in healthy adults.

This study involved 23 healthy adults who underwent baseline and post-intervention measurements of IOP and ocular structures. Using swept-source OCT(SS-OCT), we quantified Schlemm's canal area(SCAR) and trabecular meshwork thickness across four quadrants, and assessed posterior segment parameters with a 24 × 20 mm ultra-widefield protocol. Measurements were repeated at 1, 15, 30, and 60 minutes after a 5-minute standardized laughter exercise to analyze longitudinal changes and IOP correlations.

IOP significantly decreased at 1, 15, and 30 minutes after laughter exercise (all p<0.01), then recovered at 60 minutes(p=0.131). The nasal SCAR significantly enlarged at 15 minutes(p<0.001) and 30 minutes post-exercise(p=0.004). Temporal SCAR only showed significant increase at 1 minute post-exercise(p=0.025). The superior SCAR significantly enlarged at 1 minute(p=0.008) and 30 minutes(p=0.041) post-exercise. Inferior SCAR remained stable throughout the study period(p=0.204). The trabecular meshwork thickness in all 4 quadrants only exhitbited significant increase at 1 minute post-exercise(all p<0.01). No significant changes in chorioretinal parameters were noted(all p>0.05). In the multivariate model, retinal superficial capillary plexus vessel density positively corelated with IOP(β=4.00, p=0.009), whereas nasal SCAR demonstrated a negative correlation(β=-2.40, p=0.003).

The anterior and posterior segment demonstrated distinct responses to a standardized laughter exercise. The IOP changes are associated with the expansion of Schlemm's canal. Further research is warranted to determine the efficacy of laughter exercise as a non-pharmacological adjunct for IOP control.