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Updated: Jan 13, 2026

Shunt Surgery, Right Heart Catheterization, and Vascular Morphometry in a Rat Model for Flow-induced Pulmonary Arterial Hypertension
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Shunt Surgery, Right Heart Catheterization, and Vascular Morphometry in a Rat Model for Flow-induced Pulmonary Arterial Hypertension

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GLP-1受容体作動薬は、肺高血圧症におけるGSK3β-Drp1シグナル伝達の阻害により右室のミトコンドリア機能障害を軽減する

Lin Zhao1, Yanghong Liu2, Ziwei Ou1

  • 1Department of Cardiovascular Medicine, The Third Xiangya Hospital, Central South University, Changsha, 410013, China.

European journal of medical research
|January 10, 2026
PubMed

キーワード:
GLP-1受容体作動薬ミトコンドリア機能肺動脈性肺高血圧症（PAH）右室（RV）機能障害/負荷過剰

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Prostacyclin receptor agonists are a class of therapeutic agents integral to managing pulmonary arterial hypertension (PAH). These drugs operate by mimicking the action of prostaglandin I2, or PGI2, a naturally occurring compound in the body.
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Receptor tyrosine kinase inhibitors (TKIs) and calcium channel blockers (CCBs) are two critical categories of drugs employed in the treatment of pulmonary artery hypertension (PAH). PAH is a disease that causes high blood pressure in the pulmonary arteries, resulting in chest pain, fatigue, and shortness of breath.
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