成人脊柱畸形における甲状腺機能低下症
Tiffany Chu1, Munira Ali1, Vikram Murugan1
1Department of Neurosurgery, Creighton University School of Medicine, 7500 Mercy Road, Omaha, NE, 68124, USA.
Spine deformity
|January 11, 2026
まとめ
甲状腺機能低下症は、成人脊柱変形症患者においてより一般的です。この状態は、甲状腺刺激ホルモン(TSH)レベルの上昇および女性であることとともに、成人変形性脊柱側弯症におけるコブ角の重症度と関連しています。
科学分野:
- 内分泌学
- 整形外科学
- 脊椎外科
背景:
- 甲状腺機能低下症は、変形性脊椎疾患の患者においてますます認識されています。
- 成人脊柱変形症(ASD)は、臨床的な課題が増加しています。
研究 の 目的:
- 成人脊柱変形症と診断された患者における甲状腺機能低下症の有病率を調査すること。
- この患者群における脊柱の弯曲の尺度であるコブ角と甲状腺機能障害マーカーとの潜在的な相関関係を探求すること。
主な方法:
- 多施設共同後ろ向き研究により、脊柱変形症を有する成人患者(60歳以上)834名を対象にレビューを実施しました。
- 収集されたデータには、人口統計学的情報、甲状腺機能低下症の診断、甲状腺パネルの結果(TSH、遊離T4)、コブ角、および骨密度が含まれていました。
主要な成果:
- 成人脊柱変形症(ASD)患者の33.3%に甲状腺機能低下症が診断されました。
- 甲状腺機能低下症、TSH上昇、および女性は、成人変形性脊柱側弯症におけるコブ角の増大と有意に関連していました。
- 甲状腺機能低下症、遊離T4、および骨密度との間に関連は見出されませんでした。
結論:
- 成人脊柱変形症患者における甲状腺機能低下症の有病率は上昇しています。
- 甲状腺機能障害マーカー(甲状腺機能低下症、TSH)および女性は、脊柱弯曲の重症度(コブ角)の増大と相関しています。
- 甲状腺機能低下症と脊柱変形症との間の複雑な関係を解明するためには、さらなる研究が必要です。
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