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免疫複合体からの細胞外DNAの除去はDNase Iを用いた炎症制御に不可欠

Shi Chen1, Yibo Du1, Chenxu Zhu1

  • 1School of Materials Science and Engineering, Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, Sun Yat-sen University, Guangzhou, 510275, Guangdong, China.

Biomaterials
|January 11, 2026
PubMed
まとめ

過剰な細胞外DNA（cfDNA）は自己免疫疾患を悪化させる。ヘパリンと設計されたDNaseナノ粒子（DNase@TANP）は、cfDNA-免疫複合体を相乗的に分解し、炎症を抑制し、関節リウマチモデルを改善する。

キーワード:
自己免疫疾患細胞外DNADNase I免疫複合体

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