プレート式トーリック眼内レンズ移植後の有意な回転を予測するための日本人集団におけるノモグラム
Xuanqiao Lin1, Zhixiang Hua1, Wenqian Shen1
1Department of Ophthalmology, Eye, Ear, Nose, and Throat Hospital of Fudan University, Shanghai, People's Republic of China.
Purpose:
Purpose: To identify independent risk factors associated with significant postoperative rotation (≥10°) of plate-haptic toric intraocular lenses (IOLs) and to develop and externally validate a predictive nomogram.
Setting:
Two independent eye centers in China.
Design:
A prospective observational study with a training cohort and an external validation cohort.
Methods:
A total of 805 eyes from 805 cataract patients with regular corneal astigmatism (≥0.75 D) who underwent phacoemulsification and plate-haptic toric IOL implantation between August 2021 and December 2024 were included. Patients from one center formed the training cohort, while patients from the second center served as the external validation cohort.LASSO regression followed by multivariable logistic regression was used to identify predictors of significant toric IOL rotation (≥10° at 2 weeks postoperatively). A predictive nomogram was developed and validated through receiver operating characteristic (ROC) analysis, calibration curve, and decision curve analysis (DCA).
Results:
Age (OR = 1.04, p = 0.002), anterior chamber depth (ACD) (OR = 7.71, p < 0.001), lens thickness (LT) (OR = 5.13, p < 0.001) and white-to-white (WTW) (OR = 2.36, p = 0.002) were identified as independent predictors. The nomogram demonstrated good discriminative performance with an AUC of 0.809 in the training cohort and 0.848 in the Validation cohort. Calibration and DCA analyses confirmed the accuracy and clinical utility of the model.
Conclusion:
A validated nomogram based on age, ACD, LT and WTW provides a useful tool for individualized preoperative risk assessment of significant toric IOL rotation, aiding surgical decision-making.
