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Updated: Jan 13, 2026

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA

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ハダカデバネズミにおけるがんの誘発：自然防御の検証

Amy M Boddy¹, Lisa M Abegglen^2,3

¹Integrative Anthropological Sciences, University of California, Santa Barbara, Santa Barbara, California.

Cancer discovery

|January 12, 2026

Abstract:

Although mice develop lung cancer from a single Eml4-Alk driver fusion, Shepard, Lester, and colleagues show that naked mole rats require three simultaneous oncogenic events: Eml4-Alk, Tp53 loss, and Rb1 loss, achieving only 30% tumor penetrance. This inducible cancer model in naked mole rats offers a unique platform for uncovering mechanisms of cancer resistance and modeling rare pleomorphic lung carcinomas. See related article by Shepard et al., p. 35.

キーワード:

ハダカデバネズミ肺がんがん抵抗性がんモデル比較ゲノム学腫瘍抑制遺伝子

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