パーキンソン病における不安進行を予測する好中球/リンパ球比

Dehao Yang¹, Zijia Liu², Shenyi Lin³

¹Department of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China.

Movement disorders clinical practice

|January 12, 2026

要旨

Background:

Anxiety progression in Parkinson's disease (PD) and its link to peripheral inflammation remain unclear.

Objective:

This study aimed to determine whether lymphocyte-related inflammatory markers can predict the longitudinal progression of anxiety symptoms in patients with PD.

Methods:

This study utilized a large public database to evaluate 13 inflammatory markers associated with lymphocytes. Linear regression and mixed-effects models were employed to assess associations between the inflammatory indicators and anxiety symptoms.

Results:

Elevated baseline neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI) were associated with higher levels of both state and trait anxiety (P < 0.05). An increase in the NLR is indicative of the deterioration of trait anxiety (estimate = 0.455, P = 0.030), especially in late-onset PD (LOPD) patients and males.

Conclusions:

The NLR is a potential biomarker for the progression of anxiety in PD patients, indicating that neuroinflammation is related to anxiety.

キーワード:

パーキンソン病不安炎症好中球/リンパ球比

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