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Bone Disorders01:29

Bone Disorders

5.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

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The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
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Spongy Bone01:09

Spongy Bone

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All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
7.5K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

3.2K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Bone Remodeling01:40

Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Vertebral Column: Regions and Curvature01:16

Vertebral Column: Regions and Curvature

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The vertebral column or spine is a flexible column that supports the head, neck, and body and  allows for their movements. It also protects the spinal cord.
Regions of the Vertebral Column
In an adult, the spine is subdivided into five regions: the cervical, the thoracic, the lumbar, the sacral, and the coccygeal region. The spine initially develops as a series of 33 vertebrae; after 20 years of age, the nine bones in the sacral region, five sacral, and four coccygeal bones fuse to form...
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関連する実験動画

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Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
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正常な加齢集団における椎骨骨梁微細構造の変化

Chun-Hsiang Chan1,2,3, Hao-Yang Wu2, Li-Heng Chen1

  • 1Department of Geography, National Taiwan Normal University, Taipei.

Quantitative imaging in medicine and surgery
|January 12, 2026
PubMed
まとめ

骨強度には骨梁微細構造が依存しており、これは年齢および性別によって著しく変化する。高解像度CTスキャンはこれらの変化を検出し、高齢者の骨折リスク評価に役立つ。

キーワード:
コンピューテッドトモグラフィー（CT）骨粗鬆症定量的分析脊椎骨梁

さらに関連する動画

A Sectioning, Coring, and Image Processing Guide for High-Throughput Cortical Bone Sample Procurement and Analysis for Synchrotron Micro-CT
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Last Updated: Jan 13, 2026

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
06:59

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A Sectioning, Coring, and Image Processing Guide for High-Throughput Cortical Bone Sample Procurement and Analysis for Synchrotron Micro-CT
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A Sectioning, Coring, and Image Processing Guide for High-Throughput Cortical Bone Sample Procurement and Analysis for Synchrotron Micro-CT

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Author Spotlight: Enhancing Small Animal Bone Compression Testing for Research
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Author Spotlight: Enhancing Small Animal Bone Compression Testing for Research

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科学分野:

  • 整形外科学
  • 放射線学
  • 老年医学

背景:

  • 骨梁微細構造は骨強度にとって重要である。
  • 加齢集団は骨構造の変化を経験する。
  • 加齢個体における骨微細構造の性差は十分に特徴づけられていない。

研究 の 目的:

  • 加齢集団における骨梁微細構造を特徴づけること。
  • 椎骨骨構造における年齢および性別特異的な変化を特定すること。
  • 骨微細構造評価のためのマルチディテクターコンピューテッドトモグラフィー（MDCT）の有用性を評価すること。

主な方法:

  • 360人の参加者（50〜80歳）のMDCTスキャンを後方視的に分析した。
  • 参加者を性別一致の5歳刻みの年齢層に分類した。
  • L1椎骨の骨梁微細構造を専門ソフトウェアを用いて分析した。

主要な成果:

  • 特定の年齢層において、骨梁の厚さ、分離、数に著しい性差が観察された。;加齢に伴い、両性ともに骨梁数は減少した。;骨量、骨梁数、フラクタル次元は一般的に加齢とともに減少し、厚さと分離は増加したが、減少/増加率には顕著な性差があった。
  • 特定の年齢層において、骨梁の厚さ、分離、数に著しい性差が観察された。加齢に伴い、両性ともに骨梁数は減少した。骨量、骨梁数、フラクタル次元は一般的に加齢とともに減少し、厚さと分離は増加したが、減少/増加率には顕著な性差があった。

結論:

  • 椎骨骨梁微細構造は、著しい年齢および性別特異的な変化を示す。
  • 高解像度CTはこれらの構造的変化を検出できる。
  • CTベースの評価は、骨脆弱性の早期検出と個別化された骨折リスク戦略の可能性を提供する。