リサンキズマブの副作用としての肺膿瘍
Zarif Kazi1, Stuart Jesin1, Samir Ghimire1
1Internal Medicine, Department of Medicine, Maimonides Medical Center, Brooklyn, NY, USA.
European clinical respiratory journal
|January 12, 2026
まとめ
この症例は、リサンキズマブ(生物学的療法)と重篤な肺感染症との潜在的な関連性を強調するものです。リサンキズマブの長期使用に伴う感染リスクの理解には、さらなる研究が必要です。
科学分野:
- 免疫学; 肺医学; 感染症学
背景:
- リサンキズマブは長期間使用される生物学的療法です。リサンキズマブに関連する感染症リスクを特徴づけることは極めて重要です。リサンキズマブの長期治療を受けている患者は、感染症に対する感受性の増加に直面する可能性があります。
研究 の 目的:
- リサンキズマブ治療中の患者における肺膿瘍の症例を報告すること。リサンキズマブと日和見感染症との潜在的な関連性を調査すること。感染症合併症に関するリサンキズマブの安全性プロファイルを理解することに貢献すること。
主な方法:
- 乾癬と円形脱毛症の病歴があり、リサンキズマブ治療を受けている30歳男性の症例提示。臨床症状には、胸膜性胸痛、咳、血痰、発熱、筋肉痛が含まれていました。診断ワークアップには、CTスキャン、喀痰抗酸菌培養、胸水培養、Xpert MTB/RIFアッセイが含まれていました。
主要な成果:
- CTスキャンで大きな空洞性病変と胸水が特定されました。感染症の検査で結核は除外されましたが、メチシリン耐性黄色ブドウ球菌とアビウム菌が特定されました。患者はドキシサイクリンによる治療と胸腔鏡下手術によるデコーティケーションを受けました。
結論:
- この症例は、リサンキズマブと肺膿瘍の発症との間に可能性のある関連を示唆しています。リサンキズマブは免疫抑制に寄与し、重篤な感染症のリスクを高める可能性があります。この症例は、リサンキズマブ治療を受けている患者における感染症のモニタリングの重要性を強調しています。
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