慢性アキレス腱症に対する体外衝撃波療法と偽体外衝撃波療法の比較：ランダム化比較試験のメタアナリシス

Chronic Achilles tendinopathy is a persistent and debilitating condition. Extracorporeal shockwave therapy (ESWT) is widely used, but its true effectiveness and safety for chronic Achilles tendinopathy remains debated. This study aimed to compare the effectiveness and safety of ESWT and sham ESWT for chronic Achilles tendinopathy.

Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, PubMed, EMBASE, Cochrane Library, and Web of Science were systematically searched for randomized controlled trials (RCTs) comparing ESWT with sham ESWT in chronic Achilles tendinopathy. Primary outcomes included pain reduction (change in Visual Analog Scale (ΔVAS), minimal clinically important difference (MCID) 1.1/10) and functional improvement (change in Victorian Institute of Sports Assessment-Achilles (ΔVISA-A), MCID 8/100; change in American Orthopaedic Foot and Ankle Society (ΔAOFAS), MCID 12/100). Secondary outcomes encompassed adverse events. Risk of bias was assessed via Risk of Bias 2 (RoB2). Meta-analysis used RevMan 5.4.1, with weighted mean differences (WMD) and odds ratios (ORs) for continuous and dichotomous outcomes, respectively. Hypothesis-generating subgroup analyses explored ESWT type, tendinopathy classification, and symptom duration.

Eight RCTs (458 participants) were included. No significant differences were observed between ESWT and sham groups in ΔVAS or ΔVISA-A, ΔAOFAS across follow-ups all P > 0.05). Adverse events were higher with ESWT (4.5% vs. 1.2%), though non-significant (P = 0.12). Subgroup analysis found that ESWT led to significant VAS reduction in patients with symptom duration < 12 months at 1-month (WMD: -0.76, P = 0.03) and 3-month (WMD: -1.23, P = 0.001) follow-ups than Sham ESWT.

ESWT showed no clear overall benefits compared to sham ESWT for chronic Achilles tendinopathy, but exploratory analyses hint at possible short-term pain relief for patients with symptoms lasting less than 12 months. More high-quality evidence is needed.