空腹時血糖値およびHbA1cと血清25(OH)Dレベルとの関連性：前糖尿病患者を対象とした横断研究

Vitamin D is very important for insulin secretion and sensitivity, and not getting enough of it has been related to problems with glucose metabolism. Prediabetes is a stage of glucose intolerance that can be reversed. Finding modifiable risk factors, such as a lack of vitamin D, can aid with early intervention.

A cross-sectional analytical investigation was done with 120 persons between the ages of 30 and 60 who had been diagnosed with prediabetes based on HbA1c readings between 5.7% and 6.4%. We used a chemiluminescent immunoassay to find out how much 25-hydroxyvitamin D [25(OH)D] was in the serum. We put the participants into three categories based on their vitamin D levels: deficient (<20 ng/mL), insufficient (20-29 ng/mL), and sufficient (≥30 ng/mL). We looked at glycemic indicators, such as fasting blood glucose (FBG), HbA1c, and homeostatic model assessment of insulin resistance among groups.

Out of 120 people, 48 (40%) were low in vitamin D, 44 (36.7%) were not getting enough, and 28 (23.3%) were getting enough. The average FBG was much greater in the group that did not get enough vitamin D (112.3 ± 9.4 mg/dL) than in the group that did (102.1 ± 8.6 mg/dL) (P = 0.003). In the same way, the average HbA1c levels were 6.3% ±0.2% in the insufficient group and 5.9% ±0.3% in the sufficient group (P = 0.001). There was a strong negative connection between serum 25(OH)D and HbA1c (r = -0.42, P < 0.01).

A lack of vitamin D is strongly linked to poor blood sugar management in persons who are prediabetic. Checking and fixing vitamin D levels may help those who are at risk of getting type 2 diabetes delay or avoid getting it.