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Updated: Jan 13, 2026

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Preparation of Acute Human Hippocampal Slices for Electrophysiological Recordings
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小児における生理食塩水対グルコン酸/酢酸緩衝液対乳酸緩衝液の血清クロリドへの影響
Yunus Nadeemulla Beig Khader1, Sana Mehek2, Shubhanshu Gupta3
1Department of Pediatrics, Amana Healthcare, Al Ain, UAE.
Journal of pharmacy & bioallied sciences
|January 12, 2026
まとめ
静脈内輸液の組成は、小児の電解質に影響を与える。生理食塩水とは異なり、平衡輸液は小児のクロリド値を安定させ、アシドーシスを予防する可能性がある。
科学分野:
- 小児集中治療医学、臨床化学、静脈内輸液療法
背景:
- 静脈内(IV)輸液の投与は、小児科における標準的な処置である。
研究 の 目的:
- 入院中の小児患者に生理食塩水、グルコン酸/酢酸緩衝液、または乳酸緩衝液の静脈内輸液を投与した場合の血清クロリドの変化を比較すること。
主な方法:
- 90人の小児患者を対象とした前向き観察研究。
主要な成果:
- 輸液後のクロリド値は、生理食塩水群(107.2 ± 3.1 mmol/L)と比較して、平衡輸液群(グルコン酸/酢酸:103.5 ± 2.4 mmol/L;乳酸:102.9 ± 2.8 mmol/L)で有意に高かった(P < 0.001)。
- 生理食塩水の投与は、クロリド値の著しい上昇をもたらした。
- 生理食塩水の使用により、軽度のアシドーシスへの傾向が観察された。
結論:
- 小児における生理食塩水の使用は、平衡輸液よりも血清クロリドの増加と関連している。
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