下顎智歯抜歯窩治癒促進におけるフィブリンリッチ血小板（PRF）とコラーゲンメンブレンの比較評価：ランダム化比較試験

Removing impacted third molars in the lower jaw can often cause problems, such as pain, swelling, and slow regrowth of tissue. Postoperative healing is often improved using platelet-rich fibrin (PRF) and collagen membranes.

Sixty patients needing the removal of bilateral mandibular third molars were randomly assigned to the two groups (30 patients in each group). Group A used PRF put into the extraction socket, and Group B placed a collagen membrane. Pain (based on visual analog scale), swelling (measured), and soft tissue healing (using the Landry's healing index) were compared on the 3^rd, 7^th, and 14^th postoperative days. Researchers used SPSS version 25.0 with a significance of P < 0.05.

On the third day, the pain score was lower on average in the PRF group (3.2) than in the collagen group (4.5). In Group A, the swelling was lower (4.1 ± 0.6 mm) compared to Group B (5.6 ± 0.9 mm). By the fourteenth day, tissues in the PRF group (4.6 ± 0.4) scored higher for healing, proving they healed faster compared to the collagen group (3.9 ± 0.6) (P < 0.01). Everyone involved in the study reported no negative experiences.

During the first few days after having third molar teeth removed, patients who used PRF experienced better pain management, a reduction in swelling, and swifter healing of the tissues than those who used collagen membranes.