睡眠と双極性障害:出産および新生児予後との関連
Sanne M Hendriks1, Anja W M M Stevens1, Bart Geerling2
1Centre for Bipolar Disorder, Dimence Mental Health Institute, Deventer, Netherlands, Pikeursbaan 3, 7411 GT, Deventer, the Netherlands.
Journal of affective disorders
|January 12, 2026
まとめ
双極性障害の妊婦において、妊娠中期に睡眠時間が短いことは帝王切開のリスク増加と関連していましたが、統計学的に有意ではありませんでした。睡眠障害は母親の健康と産後のリスクにとって重要です。
科学分野:
- 周産期メンタルヘルス
- 睡眠医学
- 生殖精神医学
背景:
- 妊娠中の双極性障害(BD)は、母親と新生児の健康にとって特有の課題をもたらします。
- この集団における睡眠障害の影響を理解することは、効果的な管理のために不可欠です。
- 以前の研究では、BDの妊婦における睡眠パターンとその産科的および新生児予後との相関関係は、広範囲には調査されていませんでした。
研究 の 目的:
- 妊娠中の睡眠時間と質、および出産/新生児予後との関係を調査すること。
- 双極性障害と診断された妊婦の睡眠パラメータを評価すること。
- 睡眠障害と、有害な産科的または新生児イベントとの潜在的な関連を特定すること。
主な方法:
- 65人のオランダ人妊婦を対象とした前向きコホート研究(Sleepreg-Bipolar Disorder - Sleepreg-BD)。
- アクチグラフィによる睡眠の質の評価。睡眠時間は睡眠日記を使用して測定。
- 躁病症状とうつ病症状の重症度は、Altman Self-Rating Mania Scale(ASRM)およびQuick Inventory of Depressive Symptomatology(QIDS)を使用して評価されました。
主要な成果:
- 第2三半期の平均睡眠効率は76.95%、第3三半期は74.8%でした。
- 第2三半期の平均睡眠時間は408.95分、第3三半期は412.18分でした。
- 第2三半期の睡眠時間の短縮は、帝王切開のリスク増加傾向を示しましたが、交絡因子を調整した後は統計学的に有意ではありませんでした。
- 出産または新生児予後に関するその他の有意な関連は見つかりませんでした。
結論:
- このコホートでは、睡眠障害と出産/新生児予後との直接的な関連の多くは有意ではありませんでしたが、睡眠問題は臨床的に依然として重要です。
- 妊娠中の睡眠障害は、BDを持つ女性の母親の健康のために注意が必要です。
- 睡眠問題に対処することは、この集団における産後の精神医学的リスクを軽減するために重要です。
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