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Updated: Jan 14, 2026

Synthesis of an Intein-mediated Artificial Protein Hydrogel
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Published on: January 27, 2014

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耐性菌に有効なキメラペプチドグリカン加水分解酵素のリンカー工学による安定性と安全性向上

Paweł Mitkowski1,2, Elżbieta Jagielska1, Małgorzata Korzeniowska Nee Wiweger1

  • 1Laboratory of Protein Engineering, Mossakowski Medical Research Institute Polish Academy of Sciences, Warsaw, Poland.

Applied microbiology and biotechnology
|January 12, 2026
PubMed
まとめ

研究者らは、ドラッグ耐性菌であるエンテロコッカス・フェカリスやスタフィロコッカス・アウレウスと戦うために、細菌を分解する酵素である安定かつ安全なキメラエンビオティックを開発した。

キーワード:
エンテロコッカス・フェカリススタフィロコッカス・アウレウス細菌溶解酵素リンカーペプチドグリカン加水分解酵素タンパク質工学

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Peptidoglycan Synthesis01:28

Peptidoglycan Synthesis

Structure of PeptidoglycanPeptidoglycan is a vital structural component of the bacterial cell wall, providing mechanical strength and shape to the cell. It consists of repeating units of two sugars—N-acetylglucosamine (NAG) and N-acetylmuramic acid (NAM)—linked by β-1,4 glycosidic bonds. These sugar chains are cross-linked by short peptide chains, forming a mesh-like polymer that surrounds the bacterial plasma membrane.Cytoplasmic Phase – Precursor SynthesisPeptidoglycan...
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