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Updated: Jan 14, 2026

A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit

A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit

Published on: July 13, 2019

成人集中治療患者における非適合性を回避するための輸液レジメンの開発

D Meyn^1,2, T Hesener³, L Kreysing⁴

¹Apotheke des Klinikum Kassel, Klinikum Kassel, Mönchebergstraße 41-43, 34125, Kassel, Deutschland. damaris.meyn@gnh.net.

Medizinische Klinik, Intensivmedizin und Notfallmedizin

|January 13, 2026

Abstract:

The concurrent delivery of multiple infusion solutions (Y-site administration) through a single catheter lumen in intensive care patients is often unavoidable. This may lead to physicochemical incompatibilities, significantly affecting the efficacy and safety of drug therapy. The objective of this study is to develop and formulate an infusion regimen that considers the number of access points and avoids incompatibilities for adult intensive care patients. A comprehensive literature search was conducted following the ADKA-DIVI standard concentration list for continuous infusions. Manufacturer information and databases, such as STABILIS, Kingguide, and Trissel's TM 2 IV Compatibility, were used to evaluate compatibility. For frequently used combinations for which no compatibility data were available, stability data on physical compatibility were compiled. Based on this, considering 34 common active ingredients and their standard concentrations, a 4-lumen central venous catheter (CVC) infusion regimen was developed to help avoid incompatibilities in the adult intensive care unit.

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適合性薬剤投与相互作用集中治療室 Yサイト

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