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空間的および単一細胞マルチオミクスが前立腺がんの予後を予測する血管新生促進型THY1⁺線維芽細胞サブタイプを明らかにする

Yongqiang Huang¹, Chunping Xiang², Yu Wang³

¹Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical Colloge, Fudan University, Shanghai, 200032, China; Department of Urology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, 200032, China.

Translational oncology

|January 13, 2026

まとめ

がん関連線維芽細胞（CAF）は前立腺がん（PCa）の進行を駆動します。特定のTHY1陽性CAFサブセットは血管新生を介して腫瘍増殖を促進し、攻撃的なPCaの潜在的な治療標的としてTHY1およびCXCL6/CXCR2経路を強調しています。

キーワード:

血管新生 CXCL6 がん関連線維芽細胞（CAF）不均一性予後シグネチャ前立腺がん単一細胞RNAシーケンシング Thy1（CD90）腫瘍微小環境

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