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Updated: Jun 21, 2026

Analysis of the Solvent Accessibility of Cysteine Residues on Maize rayado fino virus Virus-like Particles Produced in Nicotiana benthamiana Plants and Cross-linking of Peptides to VLPs

Analysis of the Solvent Accessibility of Cysteine Residues on Maize rayado fino virus Virus-like Particles Produced in Nicotiana benthamiana Plants and Cross-linking of Peptides to VLPs

Published on: February 14, 2013

コウベエンドウモザイクウイルス免疫療法の制御放出のためのコラゲナーゼ応答性ヒドロゲルのバイオプリンティング

Zhongchao Zhao¹, Yi Xiang², Zhuohong Wu³

¹University of California San Diego, 9500 Gilman Dr., SME203C MC0448, La Jolla, La Jolla, California, 92093-0001, UNITED STATES.

|January 13, 2026

Abstract:

In this work, we developed a collagenase-responsive hydrogel system to covalently load cancer immunotherapy candidate cowpea mosaic virus (CPMV) using 3D Digital Light Processing (DLP) bioprinting technology. CPMV was functionalized with norbornene groups (CPMV-NB), which was then bioprinted into hydrogels with 8-arm polyethylene glycol (PEG) norbornene and a collagenase-cleavable peptide via photoinduced thiol-ene click chemistry. This strategy enabled stable retention of CPMV-NB within the hydrogels and achieved controlled release of CPMV-NB triggered by collagenase. Furthermore, released CPMV-NB retained its immunogenicity to stimulate immune cells.

キーワード:

バイオプリンティング制御放出ヒドロゲル免疫療法

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In Vivo Targeted Expression of Optogenetic Proteins Using Silk/AAV Films

In Vivo Targeted Expression of Optogenetic Proteins Using Silk/AAV Films

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Direct Agroinoculation of Maize Seedlings by Injection with Recombinant Foxtail Mosaic Virus and Sugarcane Mosaic Virus Infectious Clones

Direct Agroinoculation of Maize Seedlings by Injection with Recombinant Foxtail Mosaic Virus and Sugarcane Mosaic Virus Infectious Clones

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