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歯科由来間葉系幹細胞由来エクソソームによる口腔疾患治療：分類、機能化、および臨床的展望

Yuxuan Teng¹, Qijing Yang¹, Yang Zhao¹

¹Department of Prosthodontics, School and Hospital of Stomatology, Jilin University, Changchun 130021, People's Republic of China; Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Changchun 130021, People's Republic of China.

Colloids and surfaces. B, Biointerfaces

|January 13, 2026

まとめ

歯科由来間葉系幹細胞由来エクソソーム（DSC-Exos）は、抗炎症作用、免疫調節作用、および組織再生作用を示し、口腔疾患治療において有望な治療可能性を提供する。これらのエクソソームは、口腔の炎症や欠損の治療における臨床応用において大きな可能性を秘めている。

背景:

従来の口腔疾患治療は、組織再生と免疫調節において課題を抱えている。
間葉系幹細胞由来エクソソーム（MSC-Exos）は治療の可能性を示すが、免疫原性および倫理的な懸念に直面している。
歯科由来間葉系幹細胞（DSCs）は、エクソソーム産生のための豊富な供給源と低い免疫原性を提供する。

結論:

DSC-Exosは、口腔の炎症、組織欠損、および免疫調節不全に対して多面的な治療的役割を果たす。
DSC-Exosと生体材料を組み合わせることで、治療効果を高めることができる。
DSC-Exosは、様々な口腔疾患の治療および再生応用における臨床的転換のためのかなりの可能性を示す。

キーワード:

デリバリーシステム歯科由来間葉系幹細胞由来エクソソーム単離と特性評価口腔疾患組織再生

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