関連する実験動画

Updated: Jan 15, 2026

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
05:33

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines

Published on: November 9, 2020

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アロステリックPROTAC:標的型タンパク質分解の視野を広げる

Aileen Frost1, Suzanne O'Connor1, Alessio Ciulli1

  • 1Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, Dundee DD1 5JJ, United Kingdom.

Journal of the American Chemical Society
|January 13, 2026
PubMed
まとめ

アロステリック・プロテオリシス・ターゲティング・キメラ (PROTACs) は,直接の阻害ではなく近接を利用して,タンパク質の分解に新しいアプローチを提供します. この戦略は,薬の開発における選択性,有効性,および耐性管理の改善の可能性を解放します.

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Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs10:44

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

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