乳幼児期の急速眼球運動睡眠の個体発生学的発達とその調節メカニズム

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Updated: Jan 15, 2026

Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice

Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice

Published on: June 19, 2019

Xiu-Juan Zhang^1,2, Xu-Hao Gao³, An-Hong Wang¹

¹Department of Pharmacy, Gansu Provincial Hospital, Lanzhou, China.

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience

|January 14, 2026

Abstract:

Rapid eye movement (REM) sleep, also known as paradoxical sleep (PS), was first identified in humans and cats in the late 1950s. It is hypothesized to contribute to brain development by providing endogenous neural activity patterns that coincide with critical periods of maturation. We summarize the remarkable alterations in polysomnographic data, EEG power spectral analysis, and behavioural patterns during early-life REM sleep, as well as the subsequent maturation of these features and the development of regulatory mechanisms. REM sleep disturbances in early life are linked to neurodevelopmental disorders. Our review aims to elucidate changes in the main characteristics during REM sleep development and its evolutionary connection with brain development, ultimately providing a basis for promoting the prevention and treatment of various neurodevelopmental disorders.

キーワード:

乳児個体発生学的発達急速眼球運動（REM）睡眠

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Measuring Neural Mechanisms Underlying Sleep-Dependent Memory Consolidation During Naps in Early Childhood

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