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Updated: Jan 15, 2026

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid

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Published on: June 17, 2025

粘膜優位型天疱瘡に伴う表層解離性食道炎：稀で認識不足の臨床像

Amani Altaiam¹, Husam Saffo², Yousef Yahia²

¹Family Medicine, Primary Health Care Corporation, Doha, QAT.

|January 14, 2026

Abstract:

Esophagitis dissecans superficialis (EDS) is an uncommon desquamative disorder most frequently associated with chemical, thermal, and medication-related injury or bullous autoimmune diseases such as pemphigus vulgaris (PV). We report a case of mucosal-dominant PV presenting with progressive oral ulceration and symptomatic EDS in the absence of cutaneous involvement. The diagnosis was confirmed by oral mucosal biopsy demonstrating suprabasal acantholysis and positive serum anti-skin immunoglobulin G (IgG) antibodies, despite nondiagnostic direct immunofluorescence. Treatment with systemic corticosteroids resulted in rapid clinical improvement. This case underscores the importance of considering mucosal-dominant PV in patients with persistent oral ulceration and gastrointestinal symptoms that fail to respond to standard initial therapy.

キーワード:

自己免疫性嚥下障害水疱性皮膚疾患表層解離性食道炎免疫抑制療法口腔潰瘍天疱瘡剥離性粘膜

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