関連する実験動画

Updated: Jan 17, 2026

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Published on: January 15, 2022

低酸素がブラッドブリスター様動脈瘤の発生を促進する：計算流体力学研究

Siquan Cheng¹, Lunxin Liu², Yue Qiu³

¹Department of Neurosurgery and West China Biomedical Big Data Center, West China Hospital, Sichuan University, China; Biofluid Lab, Sichuan University-Pittsburgh Institute, Sichuan University, China.

Journal of biomechanics

|January 14, 2026

Abstract:

Blood blister-like aneurysms (BBAs) are a rare and severe type of aneurysms with high mortality and morbidity. While BBAs are known to occur predominantly in plateau sections, their exact cause remains unclear. This study aims to investigate the correlation between oxygen mass transport and BBA initiation with patient-specific computational fluid dynamics (CFD) methods. A group of 12 BBA patients were enrolled. The mass transport of oxygen (O₂), time-averaged wall shear stress (TAWSS) and oscillatory shear index (OSI) were analyzed. Results show that the O₂ transport rate in the region where BBA occurs is very low in for 11 out of 12 patients. This region is also associated with low TAWSS and high OSI. In conclusion, this study strongly supports that mass transport of O₂ and hemodynamics exhibit the potential to serve as a diagnostic biomarker for BBAs. Furthermore, it is important to eliminate the hypoxia region of BBA during treatment.

キーワード:

ブラッドブリスター様動脈瘤血流血行動態低酸素症酸素輸送

さらに関連する動画

Modeling the Endothelial Glycocalyx Post-Pneumonectomy in a 3D Fluidic Chip - An Approach to Fabricating a Vascular-based Organ-on-Chip System

Modeling the Endothelial Glycocalyx Post-Pneumonectomy in a 3D Fluidic Chip - An Approach to Fabricating a Vascular-based Organ-on-Chip System

Published on: September 16, 2025

An In Vitro Hemodynamic Loop Model to Investigate the Hemocytocompatibility and Host Cell Activation of Vascular Medical Devices

An In Vitro Hemodynamic Loop Model to Investigate the Hemocytocompatibility and Host Cell Activation of Vascular Medical Devices

Published on: August 21, 2020

関連する概念動画

Regulation of Angiogenesis and Blood Supply

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...

Development of Blood Vessels

Development of Blood Vessels

The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...