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Updated: Jan 17, 2026

Detection of Copy Number Alterations Using Single Cell Sequencing
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Detection of Copy Number Alterations Using Single Cell Sequencing

Published on: February 17, 2017

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CopyKitによる転移性腫瘍のコピー数サブストラクチャの解明

Junke Wang1, Darlan Conterno Minussi1, Alexander Davis1

  • 1Department of Systems Biology, UT MD Anderson Cancer Center, Houston, TX 77030, USA; Graduate School of Biological Sciences, University of Texas, Houston, TX 77030, USA.

Molecular cell
|January 14, 2026
PubMed
まとめ

この研究では、腫瘍の進化を理解するための単一細胞DNAコピー数解析ツールであるCopyKitを紹介します。複雑な腫瘍データからクローナルサブストラクチャを解決し、遺伝的系統を再構築するのに役立ちます。

キーワード:
がんゲノミクス計算上の倍数性推定コピー数解析腫瘍内不均一性転移scDNA-seq単一細胞ゲノミクス腫瘍進化

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Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
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