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Updated: Jan 17, 2026

Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS
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Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS

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エンジニアリングされたフラビン依存ハロゲネーゼは,エナチオセレクティブセミピナコール再配列によるC-C結合形成を触媒化する

Xuzhong Shen1, Paras Gupta1, Pratibha Gandhi1

  • 1Department of Chemistry, Indiana University, Bloomington, Indiana 47405, United States.

Journal of the American Chemical Society
|January 15, 2026
PubMed
まとめ

フラビン依存ハロゲネーゼは,アリルアルコールのエナチオセレクティブ半ピナコール再配列を触媒化し,キラルケトンを生成する. T52Gの変異により この新しい生物触媒的変換が可能になり 価値ある分子構造へのアクセスを拡大しました

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By replacing an α-hydrogen with a halogen, acid-catalyzed α-halogenation of aldehydes or ketones yields a monohalogenated product
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