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Updated: Jan 18, 2026

Studying Cryptosporidium Infection in 3D Tissue-derived Human Organoid Culture Systems by Microinjection

Studying Cryptosporidium Infection in 3D Tissue-derived Human Organoid Culture Systems by Microinjection

Published on: September 14, 2019

クリプトスポリジウムのライフサイクルと発生段階を標的とする化合物に関する洞察

Zoë Reynolds¹, Sumiti Vinayak¹

¹Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USA.

Current opinion in microbiology

|January 15, 2026

Abstract:

The intestinal protozoan parasite, Cryptosporidium, is a leading cause of diarrhea-associated illness and death in young children, immunocompromised individuals, and neonatal ruminant animals. This apicomplexan parasite completes its entire lifecycle within a single host, involving a timely and coordinated progression through asexual and sexual developmental stages. With no fully effective drugs or vaccines available, a deeper understanding of the parasite's lifecycle stages is crucial for identifying new molecular targets for disease intervention. In this review, we discuss recent advances in understanding the Cryptosporidium developmental lifecycle, stage-specific gene expression, and the role of parasite proteins in invasion, asexual proliferation, and sexual stages. We also discuss the lifecycle stages targeted by a few highly effective anticryptosporidial compounds.

キーワード:

クリプトスポリジウムライフサイクル遺伝子発現薬剤標的下痢寄生虫分子生物学感染症ワクチン治療法

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