分子量エンジニアリングされたレンチナン画分は、プレバイオティクスモジュレーターとして：精密肥満介入のための腸内細菌叢の誘導
1College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China; Key Laboratory of Environment Correlative Dietology (Huazhong Agricultural University), Ministry of Education, China.
Food research international (Ottawa, Ont.)
|January 15, 2026
まとめ
Lentinula edodes由来のレンチナン画分は、肥満予防の可能性を示しています。その分子量は腸内細菌叢に影響を与え、有益な細菌を促進し、主要な酸を生成することで、精密栄養の基盤を提供します。
科学分野:
- Microbiology; Nutrition Science; Biochemistry
背景:
- Lentinus edodes polysaccharides, particularly lentinan, are known for health benefits linked to gut microbiota interactions.; Gut dysbiosis is associated with obesity, highlighting the need for microbiota-modulating interventions.
研究 の 目的:
- To investigate the in vitro effects of three molecular weight (Mw) fractions of water-soluble lentinan (WSL) on gut microbiota from healthy and obese individuals.; To assess the potential of WSL fractions in preventing diet-induced obesity and alleviating gut dysbiosis.; To determine if the Mw gradient of lentinan acts as a directional regulator of gut microbiota.
主な方法:
- Utilized an in vitro fermentation model with gut microbiota from healthy and obese individuals.; Investigated three distinct molecular weight fractions of water-soluble lentinan: WSL-40 (2.19 × 10^6 Da), WSL-60 (2.96 × 10^5 Da), and WSL-80 (1.70 × 10^4 Da).; Analyzed changes in microbial composition, including specific genera and the Firmicutes/Bacteroidetes ratio, and measured butyric acid production.
主要な成果:
- In healthy microbiota, WSL-80 promoted Parabacteroides growth and maximal butyric acid production, indicating obesity prevention potential.; In obese microbiota, WSL alleviated dysbiosis, with lower Mw fractions progressively reducing the Firmicutes/Bacteroidetes ratio.; WSL-80 increased Phascolarctobacterium and Klebsiella, WSL-60 and WSL-80 increased Bacteroides, and WSL-40 increased Weissella.
結論:
- Lentinan's molecular weight gradient serves as a directional regulator of functional gut microbiota.; These findings provide a theoretical foundation for using lentinan fractions in precision nutrition strategies to combat obesity.; The study demonstrates the Mw-dependent effects of lentinan on gut microbiota composition and function.
