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Updated: Jan 17, 2026

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis
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多発性骨髄腫におけるGPRC5D標的T細胞エンゲージャーへの多峰性抗原エスケープ

Holly Lee1, Sungwoo Ahn1, Gerone A Gonzales2

  • 1Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, Alberta, Canada.

Nature medicine
|January 15, 2026
PubMed
まとめ

多発性骨髄腫患者はGPRC5D遺伝子変化を通じてT細胞エンゲージャー療法への耐性を獲得する。これらの変化により、がん細胞は治療を回避し、持続的な寛解を妨げるため、新たな治療戦略が必要となる。

キーワード:
多発性骨髄腫T細胞エンゲージャーGPRC5D抗原エスケープ薬剤耐性

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