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Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
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Esophageal Varices-II: Clinical Features and Management

Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
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Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
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Cushing Syndrome I: Introduction

Cushing syndrome refers to the collection of clinical manifestations that arise when tissues are exposed to excessive amounts of cortisol or cortisol-like medications over an extended period. Cortisol, a glucocorticoid produced by the adrenal cortex, regulates metabolism, immune responses, and the body’s adaptation to stress. When its concentration remains chronically elevated, these physiological pathways become dysregulated, resulting in the characteristic features of the syndrome.Exogenous...
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Cushing Syndrome II: Pathophysiology

Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...

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カプラン症候群:症例報告

Ali Moussa Mahaman Laouali1, Maïga Soumaila1, Ismael Ayouba Tinni2

  • 1Department of Pulmonology Yalgado Ouédraogo University Hospital Center Ouagadougou Burkina Faso.

Clinical case reports
|January 16, 2026
PubMed
まとめ
この要約は機械生成です。

塵肺症と関節リウマチのまれな組み合わせであるカプラン症候群は、しばしば見逃されています。この症例は、シリカ曝露者、特に鉱山労働者における関節リウマチ性肺塵症を認識することの重要性を強調しています。

キーワード:
カプランコリネ関節リウマチ関節リウマチ性肺塵症塵肺症

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科学分野:

  • リウマチ学
  • 肺学
  • 労働医学

背景:

  • カプラン症候群、または関節リウマチ性肺塵症は、塵肺症と関節リウマチを組み合わせたまれな状態です。
  • シリカ粉塵への曝露は、さまざまな呼吸器および全身性疾患の既知のリスク因子です。
  • この状態は、特に粉塵曝露が多い集団において、しばしば見逃されています。

研究 の 目的:

  • 金鉱山労働者におけるカプラン症候群の症例を提示すること。
  • このまれな状態に対する臨床的認識の重要性を強調すること。
  • 関節リウマチ性肺塵症の診断上の課題と管理について論じること。

主な方法:

  • 20年間の職業歴を持つ39歳の金鉱山労働者の症例検討。
  • 慢性進行性多発性関節炎および発熱性文脈を含む臨床像の分析。
  • 臨床的および臨床検査的検査による診断確認。

主要な成果:

  • 患者は、機能障害を伴う、小関節および大関節に影響を与える両側性、対称性の多発性関節炎を呈しました。
  • 臨床像は、慢性的な発熱経過を特徴としていました。
  • 患者の病歴と臨床所見に基づいて、カプラン症候群の診断が確立されました。

結論:

  • カプラン症候群は、シリカ粉塵に曝露された個人において、まれではあるが重要な状態です。
  • 見逃される可能性があるため、早期の認識と診断が重要です。
  • 関節リウマチ性肺塵症の患者には、集学的管理と厳密なフォローアップが不可欠です。