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関連する概念動画

Membrane Fluidity01:26

Membrane Fluidity

14.5K
Membrane fluidity is explained by the fluid mosaic model of the cell membrane, which describes the plasma membrane structure as a mosaic of components—including phospholipids, cholesterol, proteins, and carbohydrates—that gives the membrane a fluid character.
Mosaic nature of the membrane
The mosaic characteristic of the membrane helps the plasma membrane remain fluid. The integral proteins and lipids exist as separate but loosely-attached molecules in the membrane. The membrane is...
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Membrane Fluidity01:23

Membrane Fluidity

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Cell membranes are composed of phospholipids, proteins, and carbohydrates loosely attached to one another through chemical interactions. Molecules are generally able to move about in the plane of the membrane, giving the membrane its flexible nature called fluidity. Two other features of the membrane contribute to membrane fluidity: the chemical structure of the phospholipids and the presence of cholesterol in the membrane.
173.1K
Lipids as Anchors01:32

Lipids as Anchors

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In the plasma membrane, the lipids forming the bilayer can also act as an anchor to tether proteins to the membrane. The three main types of lipid anchors found in eukaryotes are – prenyl groups, fatty acyl groups, and glycosylphosphatidylinositol or GPI groups. Prenyl and fatty acyl groups act as anchors on the cytosolic surface of the membrane, whereas GPI anchors proteins on the extracellular side.
The carboxy-terminal of most of the prenylated proteins, such as Ras proteins, contains...
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Biosynthesis of Lipids01:29

Biosynthesis of Lipids

532
Microbial membranes exhibit remarkable diversity in lipid composition, reflecting evolutionary adaptations to various environmental conditions. The three domains of life—Bacteria, Archaea, and Eukarya—synthesize membrane lipids through distinct biosynthetic pathways, leading to fundamental structural differences that impact membrane stability, function, and adaptability.Fatty Acid-Based Lipids in Bacteria and EukaryaBacteria and eukaryotes share a common fatty acid biosynthesis...
532
Assembly of the Lipid Bilayer in the ER01:28

Assembly of the Lipid Bilayer in the ER

4.0K
Biological membranes are more than just a barrier separating cell cytoplasm from the outside environment. They are highly dynamic and help maintain the integrity and physiological stability of the cells as well as membrane-bound organelles. Membranes also play vital roles in cell-to-cell and intracellular communication.
A large chunk of any biological membrane is composed of phospholipids. These lipids have a heterogeneous distribution across different subcellular organelles and even between...
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Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

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Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
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Formulation and Characterization of Bioactive Agent Containing Nanodisks
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Formulation and Characterization of Bioactive Agent Containing Nanodisks

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高濃度ラムノリピド製剤：化学的多様性と構造、流動挙動、機能性の架け橋

Matilde Tancredi1,2, Carlo Carandente Coscia1,2, Michela Buonocore1

  • 1Department of Chemical Sciences, University of Naples Federico II, Complesso Universitario di Monte Santangelo, Via Cintia 4, Naples I-80126, Italy.

ACS sustainable chemistry & engineering
|January 16, 2026
PubMed
まとめ

本研究は、特にラムノリピドであるバイオサーファクタントが、安定で超高濃度なバイオベース製剤の作成に優れていることを示しています。そのユニークな組成により、高濃度でも一貫したミセル構造を維持し、低粘度と洗浄力を保つことができます。

キーワード:
バイオサーファクタントコングナー混合物環境持続可能な洗剤レオロジー自己集合超高濃度製剤

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Single-Molecule Diffusion and Assembly on Polymer-Crowded Lipid Membranes
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Fabrication Procedures and Birefringence Measurements for Designing Magnetically Responsive Lanthanide Ion Chelating Phospholipid Assemblies
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Fabrication Procedures and Birefringence Measurements for Designing Magnetically Responsive Lanthanide Ion Chelating Phospholipid Assemblies

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Single-Molecule Diffusion and Assembly on Polymer-Crowded Lipid Membranes
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Fabrication Procedures and Birefringence Measurements for Designing Magnetically Responsive Lanthanide Ion Chelating Phospholipid Assemblies
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科学分野:

  • 持続可能な製品設計
  • バイオベース製剤
  • 界面活性剤化学

背景:

  • 超高濃度バイオベース製剤は、持続可能な製品設計における重要な分野である。
  • バイオサーファクタントは、製剤の構造と機能を最適化するための天然の化学的多様性を提供する。

研究 の 目的:

  • 市販のラムノリピドサンプルの組成を調査する。
  • 水溶液中でのラムノリピドの自己集合挙動を特徴づける。
  • 製剤特性におけるラムノリピドコングナー組成と遊離脂肪酸の役割を理解する。

主な方法:

  • 組成分析のための核磁気共鳴（NMR）および質量分析。
  • 構造特性評価のための偏光顕微鏡、小角X線散乱（SAXS）、電子常磁性共鳴（EPR）。
  • 濃度および温度変動研究。

主要な成果:

  • ラムノリピドサンプルは、主にジラムノリピドと二重鎖種、および遊離脂肪酸からなる複雑なコングナー混合物である。
  • 水性ラムノリピド溶液は、濃度（65重量%まで）と温度（50°Cまで）に依存しない安定な楕円体ミセルを疎水性コアとして形成する。
  • 65重量%以上の濃度では、コングナーの分離が秩序だった構造をもたらし、低粘度と洗浄効率を維持する。

結論:

  • ラムノリピドコングナー組成と遊離脂肪酸は、自己集合と製剤特性の調整に不可欠である。
  • 観察された凝集挙動は、高濃度ラムノリピド製剤の低粘度と洗浄効率の維持を説明する。
  • ラムノリピドは、革新的で持続可能な製剤開発のための有望な候補である。