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Updated: Jan 18, 2026

Identification of Alternative Splicing and Polyadenylation in RNA-seq Data
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Identification of Alternative Splicing and Polyadenylation in RNA-seq Data

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PolyA-GLM: ゲノム言語モデルを用いたデノボ（ De novo ）ポリアデニル化部位予測のための包括的フレームワーク

Sourav Saha1, Naima Ahmed Fahmi1, Jeongsik Yong2

  • 1Department of Computer Science, University of Central Florida, Orlando, FL, USA.

Computational and structural biotechnology journal
|January 16, 2026
PubMed
まとめ

ゲノム言語モデル（GLM）は、遺伝子発現調節に不可欠なポリアデニル化（poly(A)）部位を正確に予測する。本研究では、RNAプロセシングの洞察を強化するパイプライン、PolyA-GLMを紹介する。

キーワード:
種間テストデノボポリアデニル化部位予測少数ショット学習ゲノム言語モデル転写後調節トランスフォーマーモデル

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Author Spotlight: Exploring the Frontier of mRNA Research with Poly A Tail Analysis Techniques08:16

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関連する概念動画

Leaky Scanning02:28

Leaky Scanning

During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R...
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