脳卒中後の認知機能障害に対する遠隔リハビリテーションの効果に関する単盲検無作為化試験：CIPS-TER研究：根拠、デザイン、および方法論

Eleonora Barucci¹, Arianna Cavaliere¹, Eleonora Pavan²

¹Neuroscience Section, NEUROFARBA Department, University of Florence, Florence, Italy.

Frontiers in stroke

|January 16, 2026

要旨

Background And Aims:

Cognitive impairment (CI) after stroke is still a neglected consequence compared to other neurological deficits for which rehabilitation pathways are routinely available. Cognitive teleRehabilitation (CTR) represents an emerging approach that has the potential to reduce healthcare costs and potentially reaching many patients. By means of a randomized controlled trial, the aims are to investigate the prevalence of cognitive impairment after stroke and the efficacy of a CTR program in: (a) reducing the risk of CI 6 months after stroke; (b) generalizability of the cognitive training to real life; (c) impact on cognitive performances. In the treated group, feasibility, adherence and appreciation of the CTR will also be evaluated.

Methods And Outcomes:

The CIPS-TER study is a 2-year prospective, single-blind, randomized clinical trial. One hundred patients with ischemic or hemorrhagic stroke will be enrolled in the study, within 5-21 days after onset, and randomized to treatment or standard care. The CTR program will consist of up to 40 h (8 weeks) of individual treatment based on memory, attention, executive functions, and visuospatial tasks to be autonomously performed with a tablet. The study outcomes will be evaluated at 6-month follow-up visit and will include the diagnosis of cognitive impairment, activities of daily living, quality of life, changes in frailty status and cognitive efficiency.

Conclusions:

CIPS-TER study will expand our knowledge on the potential effect of cognitive rehabilitation on future cognitive and functional decline after stroke.

キーワード:

認知機能障害認知リハビリテーション脳卒中後認知機能障害脳卒中遠隔リハビリテーション

さらに関連する動画

07:35

Author Spotlight: Rehabilitation of Stroke Patients With a Digital Occupational Training System

Published on: December 29, 2023

1.9K

08:53

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke

Published on: June 6, 2025

1.6K

関連する概念動画

02:07

Blind Procedures

Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which child was...

01:11

Blinding

Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.