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Updated: Jan 18, 2026

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薬剤耐性を持ったカンジダ・アウリスは、選択圧なしで薬剤耐性を獲得する可能性がある

Trinh Phan-Canh, Duc-Minh Nguyen-Le, Manju Chauhan

bioRxiv : the preprint server for biology

|January 16, 2026

まとめ

カンジダ・アウリスは、抗真菌薬への曝露なしに、実験室での輸送中に薬剤耐性と形態を変化させる可能性があります。これは、 mycology 研究所間で臨床株を交換する際の標準化されたプロトコルの必要性を強調しています。

科学分野:

医療菌学
薬剤耐性
ゲノミクス

背景:

カンジダ・アウリスは、高い死亡率を伴うアウトブレイクを引き起こす重要なヒト真菌病原体です。
治療の失敗は、抗真菌薬耐性と株のばらつきに関連しています。
種内変異と誘発された高変異は、病原性と治療の失敗に寄与します。

主な方法:

CDC mycoSNPsパイプラインを使用した全ゲノムシーケンシング。
Clinical and Laboratory Standards Institute（CLSI）ガイドラインに従った抗真菌薬感受性試験。
遺伝的およびエピジェネティックな変化を誘発するためのろ紙輸送条件をシミュレートする実験。

結論:

カンジダ・アウリスは、抗真菌薬への曝露なしに薬剤耐性に影響を与える変異を獲得する可能性があります。
日常的な株の取り扱いと交換は、大幅な遺伝的および表現型の多様化につながる可能性があります。
臨床C. auris株の交換のための標準化されたプロトコルは、信頼できる研究と診断に不可欠です。

キーワード:

Candida auris antifungal resistance morphogenesis strain exchange genomic variation filter paper shipment

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