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Updated: Jan 18, 2026

Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS

Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS

Published on: June 20, 2014

PhI(OCOCF₃)₂を介したインドールの金属フリー2,3-ジ官能基化：カルボカルコゲン化骨格への直接アクセス

Satyajit Pal¹, Subhankar Sarkar¹, Tanmay Pramanik¹

¹Department of Chemistry, Visva-Bharati (A Central University), Santiniketan, 731235, West Bengal, India. adinath.majee@visva-bharati.ac.in.

Chemical communications (Cambridge, England)

|January 16, 2026

Abstract:

We report a metal-free approach for the oxidative difunctionalization of indole moieties using a hypervalent iodine reagent. This protocol facilitates a metal-free, environmentally friendly, and efficient oxidative C(sp²)-H coupling reaction that utilises indole, naphthoquinones, and diphenyl dichalcogenides. The method has been designed so that it should run under mild conditions to enable the formation of C(sp²)-C and C(sp²)-S/Se bonds with good yields and a wide range of relevant substrates. Additionally, our approach offers a valuable pathway for the modification of drug molecules, which further enhances its utility in organic synthesis.

キーワード:

金属フリー合成インドール C-H官能基化高原子価ヨウ素試薬ジ官能基化カルボカルコゲン化

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Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives

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Published on: January 19, 2016

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy

Published on: November 9, 2019

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