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Nucleotide Excision Repair01:38

Nucleotide Excision Repair

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DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
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Nucleotide Excision Repair01:08

Nucleotide Excision Repair

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Overview
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Neural Regulation01:37

Neural Regulation

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Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
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Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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関連する実験動画

Updated: Jan 18, 2026

Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly
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Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly

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NERにおける病変認識と切除認識

Jochen Kuper1, Caroline Kisker1

  • 1Rudolf Virchow Center for Integrative and Translational Bioimaging, University of Wuerzburg.

DNA repair
|January 16, 2026
PubMed
まとめ

ヌクレオチド除去修復（NER）は、重要なDNA修復経路です。このレビューは、NERにおける最近の構造生物学の発見、特に病変認識と切開シグナル伝達に焦点を当てて強調しています。

科学分野:

  • 分子生物学
  • 遺伝学
  • 生化学

背景:

  • ヌクレオチド除去修復（NER）は、用途の広いDNA修復メカニズムです。
  • UV誘発損傷や嵩高い付加物など、さまざまなDNA病変を修正します。
  • 真核生物のNERは、正確な病変処理のために30以上のタンパク質を必要とします。

研究 の 目的:

  • NER研究における最近の進歩をレビューすること。
  • 病変の探索、検証、切開シグナル伝達に関する構造生物学の洞察に焦点を当てること。

主な方法:

  • 構造生物学（高解像度構造）
  • 生化学
  • 計算生物学

主要な成果:

  • NER複合体の組み立てと病変の引き継ぎに関する理解の深化。
  • 病変検証メカニズムの洞察。
  • DNA切開を引き起こす可能性のあるシグナル伝達経路。

結論:

  • 構造生物学はNERメカニズムを解読するための鍵です。
キーワード:
グローバルゲノム修復XPDヌクレオチド除去修復TFIIH転写カップル修復XPB

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  • さらなる研究により、正確な切開シグナル伝達経路が解明される可能性があります。