骨粗鬆症治療薬における10年間の進歩とパラダイムシフト：文献計量学的分析

Despite extensive research on osteoporosis therapies, systematic analysis of knowledge evolution and translational bottlenecks remains unexplored. This study presents the multidimensional bibliometric analysis of 10,247 publications (2015-2024) to decode paradigm shifts in osteoporosis therapeutics. Using CiteSpace and VOSviewer for bibliometric and visualization analyses, we observed a notable increase in annual publications, peaking in 2022. China and the United States led in research output, while European countries demonstrated higher citation impact. Shanghai Jiao Tong University, Harvard Medical School, and Chinese Academy of Sciences were the top three contributing institutions. Cooper, Cyrus is the most influential author. In academic publishing, Osteoporosis International has been identified as the journal with the most research results in the field of osteoporosis treatment. Keyword emergence analysis revealed a transition in research focus from randomized controlled trial and ovariectomized rats to drug, discontinuation, osteogenesis, bisphosphonate related osteonecrosis, network pharmacology, molecular docking, reduction, fixation, damage, American association, osteoporotic fracture, gut microbiota in the last five years, and that this is being explored in detail for future work. In summary, this study offers a thorough bibliometric analysis of osteoporosis therapeutics worldwide, providing scholars conducting analogous research in this field with valuable insights.