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Updated: Jan 20, 2026

Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD

Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD

Published on: October 10, 2012

PTSDにおけるヒト海馬の免疫不均衡：単核転写解析による解明

Liu Liu¹, Pengfei Li¹, Brent A Wilkerson²

¹Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, United States.

Frontiers in immunology

|January 19, 2026

まとめ

心的外傷後ストレス障害（PTSD）は、脳内の免疫不均衡を伴い、グリア細胞の活動変化や神経細胞とのコミュニケーション低下が見られる。海馬におけるこの神経免疫機能不全は、PTSDの発症機序に寄与する。

キーワード:

PTSD ヒト海馬免疫不均衡神経炎症 snRNAシーケンス

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Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD

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We describe a rat model of post traumatic stress disorder (PTSD) that reveals the persistent alterations in neuroendocrine function and the delayed long-term, exaggerated fear response, characteristic of PTSD patients. The animal model and methods described here are useful for correlating biomarkers in brain nuclei, which are mechanistic but cannot be measured in patients, with biomarkers in peripheral white blood cells, which...

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