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Updated: Jan 20, 2026

Testing the In Vitro and In Vivo Efficiency of mRNA-Lipid Nanoparticles Formulated by Microfluidic Mixing
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pH上昇に伴い段階的に起こるmRNA-脂質ナノ粒子調製中のバッファー交換によって誘発される形態学的変化

Yujia He1, Emily H Pilkington1, Hee Jung Kang1

  • 1Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.

Molecular therapy. Methods & clinical development
|January 19, 2026
PubMed
まとめ

イオン化可能な脂質ナノ粒子（LNP）は、製造バッファー交換中に構造変化を起こす。粒子融合とブレブ形成は中間pHで起こり、脂質の種類はpH 7.4での最終構造に影響を与える。

キーワード:
LNPSAXScryo-EM脂質ナノ粒子イオン化可能な脂質pKa形態学的変化形態粒子融合

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