チタン表面上のシコニン含有多孔質グラフィンナノフィルムによる抗菌活性および骨結合の強化

Bacterial infection, peri-implant inflammation, and poor osseointegration are primary causes of failure in titanium (Ti)-based implants. Surface functionalization provides a simple and effective strategy to overcome these challenges. In this study, we developed a multifunctional coating based on porous graphdiyne (GDY) nanofilm loaded with shikonin (Skn). GDY was synthesized on Ti surfaces via a copper-catalyzed reaction to form a porous nanostructure. Following Skn loading, a composite layer of tannic acid (TA) and poly (N-isopropylacrylamide) (pNIPAM) was applied, resulting in the Ti-GDY@Skn-TP system. Upon near-infrared (NIR) irradiation, the GDY coating induced localized photothermal effects sufficient to eradicate bacteria. Concurrently, the thermo-responsive release of Skn suppressed early inflammation and promoted osseointegration by regulating macrophage polarization and inflammatory cytokine secretion. In vivo studies confirmed that Ti-GDY@Skn-TP implants effectively eliminated bacterial infections, attenuated acute inflammation, and enhanced bone tissue regeneration and implant integration. This multifunctional approach offers a promising strategy for the surface modification of Ti-based biomedical implants.