関連する実験動画

Updated: Jan 20, 2026

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

Published on: June 28, 2021

タキソール誘発性高トリグリセリド血症を合併した急性膵炎の1例報告

Rahul Chowdhary¹, Kirti Arora², Rishi Chowdhary³

¹Internal Medicine, North Delhi Municipal Corporation Medical College & Hindu Rao Hospital, New Delhi, IND.

|January 19, 2026

まとめ

パクリタキセル化学療法は、高トリグリセリド血症および急性膵炎を引き起こす可能性があります。このまれで重篤な副作用を管理するには、早期の脂質レベルモニタリングと迅速な介入が不可欠です。

背景:

パクリタキセルは既知の副作用を持つ化学療法剤である。
高トリグリセリド血症および急性膵炎は、パクリタキセルに関連するまれであるが重篤な合併症である。
パクリタキセル療法を受けている患者にとって、脂質プロファイルのモニタリングは不可欠である。

結論:

パクリタキセル誘発性高トリグリセリド血症を合併した急性膵炎は、これらの症状を呈する患者において、もっともらしい診断である。
重篤な合併症を防ぐためには、脂質プロファイルの綿密なモニタリングと迅速な介入が不可欠である。
この有害事象のメカニズムと危険因子を理解するためには、さらなる研究が必要である。

キーワード:

急性膵炎乳がん化学療法高トリグリセリド血症パクリタキセル

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Animal models for severe acute pancreatitis enable the study of pathophysiological changes at the initial stage, facilitating observation of the evolution of inflammatory events. Here we provide a protocol for the induction of severe acute biliary pancreatitis by retrograde infusion of sodium taurocholate into the pancreatic duct of anesthetized C57BL/6 mice.

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