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Updated: Jan 20, 2026

Dialysis: Diffusion Based Separation

Dialysis: Diffusion Based Separation

Published on: April 30, 2023

透析患者におけるループスが全死因、心血管死、感染症関連死に与える影響：沖縄透析研究レジストリ

Nanako Oshiro¹, Yukiko Hasuike², Kentaro Kohagura¹

¹Dialysis Unit, University Hospital of the Ryukyus, Okinawa, Japan.

Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy

|January 19, 2026

要旨

Introduction:

Lupus nephritis is one of the most serious complications of systemic lupus erythematosus (SLE) and can lead to end-stage kidney disease (ESKD). We aimed to assess the relative mortality risk associated with SLE among dialysis patients.

Methods:

This retrospective longitudinal cohort study included all dialysis patients in the Okinawa Dialysis Study 30 registry. Cox proportional hazard models were performed to assess mortality.

Results:

Of 5246 patients, 111 had ESKD secondary to SLE. Compared with ESKD patients secondary to other causes, those with SLE had significantly higher risk of death (HR 2.55, 95% CI 1.81-3.47, p < 0.0001), cardiovascular death (HR 1.94, 95% CI 1.13-3.33, p = 0.0158), and infection death (HR 4.21, 95% CI 2.40-7.37, p < 0.0001) after adjusting for age, era of dialysis initiation, and sex.

Conclusion:

SLE may be independently associated with an increased risk of death in dialysis patients.

キーワード:

SLE 透析死亡率

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