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関連する概念動画

Physiology of the Gastrointestinal System I: Ingestion and Propulsion01:22

Physiology of the Gastrointestinal System I: Ingestion and Propulsion

1.8K
The physiology of the gastrointestinal system begins with ingestion as food enters the mouth.
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Physiology of the Gastrointestinal System II: Digestion and Absorption01:22

Physiology of the Gastrointestinal System II: Digestion and Absorption

1.8K
The gastrointestinal (GI) tract, extending from the mouth to the anus, plays a pivotal role in the digestion and absorption of nutrients. This process involves both mechanical and chemical actions facilitated by various enzymes.
Digestion begins in the mouth, where food undergoes mechanical breakdown by chewing and combines with saliva. Salivary amylase, an enzyme in saliva, starts the breakdown of starches into maltose. The food then travels down the esophagus to the stomach.
In the stomach, a...
1.8K
Physiology of the Gastrointestinal System III: Elimination01:26

Physiology of the Gastrointestinal System III: Elimination

1.4K
The gastrointestinal elimination process involves a complex interplay of neural and hormonal mechanisms that coordinate the final waste removal from the body. This intricate operation encompasses the absorption of water and electrolytes, vital for transforming the remaining indigestible food matter into feces. The large intestine is pivotal in water and electrolyte absorption, forming feces from unabsorbed minerals, undigested food, bacteria, bile pigments, and shed epithelial cells. Essential...
1.4K
Physiological Control of Respiration01:23

Physiological Control of Respiration

5.9K
Introduction
Breathing, a seemingly passive process, is regulated by the respiratory center in the brainstem. This center coordinates the involuntary control of respirations, which means it occurs without conscious effort, ensuring a smooth and uninterrupted pattern.
Regulation of Ventilation
The body maintains ventilation by monitoring levels of carbon dioxide (CO2), oxygen (O2), and hydrogen ion concentration (pH) in the arterial blood. Among these factors, the level of CO2 plays a crucial...
5.9K
A Strategy for the Study of IL-9-Producing Lymphoid Cells in the Nippostrongylus brasiliensis Infection Model08:38

A Strategy for the Study of IL-9-Producing Lymphoid Cells in the Nippostrongylus brasiliensis Infection Model

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IL-9-expressing T and ILC2 cells are induced during N. brasiliensis infection, yet their characterization has been largely overlooked in the infected intestine due to their low frequency and differential kinetics. This protocol describes the isolation of these cells from different target organs and confirmation of their identity via flow cytometry at different infection...
1.7K
Profiling Luminal pH in Three-Dimensional Gastrointestinal Organoids Using Microelectrodes08:24

Profiling Luminal pH in Three-Dimensional Gastrointestinal Organoids Using Microelectrodes

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The present protocol describes pH measurements in human tissue-derived gastric organoids using microelectrodes for spatiotemporal characterization of intraluminal physiology.
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関連する実験動画

Updated: Jan 20, 2026

Physiology of the Gastrointestinal System I: Ingestion and Propulsion
01:22

Physiology of the Gastrointestinal System I: Ingestion and Propulsion

1.8K

管理されたヒト鉤虫感染中の消化管生理学的変化の探索的研究

Thomas C Mules1,2, Mali Camberis1, Brittany Lavender1

  • 1Malaghan Institute of Medical Research, Wellington, New Zealand.

American journal of physiology. Gastrointestinal and liver physiology
|January 19, 2026
PubMed
まとめ
この要約は機械生成です。

健康な成人における管理された鉤虫感染は、腸管通過時間や運動性に影響を与えることなく、十二指腸および小腸のpHを一時的に低下させます。この発見は、鉤虫の理解にとって重要です

キーワード:
鉤虫感染SmartPill消化管生理学腸内pH運動性

さらに関連する動画

Physiology of the Gastrointestinal System II: Digestion and Absorption
01:22

Physiology of the Gastrointestinal System II: Digestion and Absorption

1.8K
Physiology of the Gastrointestinal System III: Elimination
01:26

Physiology of the Gastrointestinal System III: Elimination

1.4K

関連する実験動画

Last Updated: Jan 20, 2026

Physiology of the Gastrointestinal System I: Ingestion and Propulsion
01:22

Physiology of the Gastrointestinal System I: Ingestion and Propulsion

1.8K
Physiology of the Gastrointestinal System II: Digestion and Absorption
01:22

Physiology of the Gastrointestinal System II: Digestion and Absorption

1.8K
Physiology of the Gastrointestinal System III: Elimination
01:26

Physiology of the Gastrointestinal System III: Elimination

1.4K

科学分野:

  • 消化器病学;感染症;ヒト生理学

背景:

  • 鉤虫感染は世界中で4億人以上に影響を与え、消化管の問題を引き起こすが、その生理学的影響は不明である。;管理されたヒト鉤虫感染は、腸疾患の治療法となる可能性がある。

研究 の 目的:

  • 健康な成人における実験的なアメリカ鉤虫感染が消化管の通過、運動性、および管腔内pHに及ぼす影響を評価すること。

主な方法:

  • 10人の健康な成人をアメリカ鉤虫幼虫に感染させた。;消化管パラメータは、ベースライン、急性（6週）、および慢性（24〜48週）感染段階でSmartPill™ワイヤレス運動カプセルを使用して測定した。

主要な成果:

  • 急性感染中に十二指腸および小腸のpHが一過性に低下し、慢性期までに正常化した。
  • 胃排出、小腸、結腸、または全腸管通過時間に有意な変化は観察されなかった。
  • 管腔内圧、収縮頻度、または運動性指数に有意な変化は検出されなかった。

結論:

  • 健康な成人における管理されたアメリカ鉤虫感染は、十二指腸および小腸のpHを一時的に低下させる。;持続的な消化管通過または運動性の障害がないことは、治療研究のための管理された鉤虫感染の安全性を支持する。