関連する実験動画

Updated: Jan 21, 2026

Author Spotlight: Investigating the Mechanisms and Inducing Models of Polycystic Ovary Syndrome

Author Spotlight: Investigating the Mechanisms and Inducing Models of Polycystic Ovary Syndrome

Published on: July 5, 2024

診断された多嚢胞性卵巣症候群と重度の周産期合併症

Maria A Hincapie, Joel G Ray, Jonas Shellenberger

Gynecologic and obstetric investigation

|January 19, 2026

要旨

Objectives:

Women with pre-pregnancy polycystic ovary syndrome (PCOS) may face higher risks during pregnancy, yet evidence on its link to severe maternal morbidity (SMM) is limited. This population-based study addresses these gaps.

Design:

Population-based cohort study using linked administrative health data from Ontario, Canada. All hospital livebirths and stillbirths 2006-2021, in women aged 15-50 years were included.

Participants/Materials, Setting, Methods:

PCOS was identified using a validated algorithm combining diagnostic codes for PCOS or hirsutism with irregular menses. Among 1,596,228 pregnancies, 110,910 (6.9%) had prior PCOS, diagnosed a median 11 years before delivery.

Results:

Women with PCOS were older and more often obese. SMM occurred in 2.6 vs. 2.2 per 100 births among women with and without PCOS, respectively (adjusted relative risk 1.10, 95% CI 1.06-1.15).

Limitations:

Limitations include potential residual confounding and misclassification inherent in administrative data.

Conclusions:

Polycystic Ovary Syndrome confers a modest but significant increase in severe maternal morbidity, underscoring the need for targeted risk assessment and preventive strategies. Awareness of this association may inform clinical risk assessment and management strategies to mitigate serious maternal complications.

キーワード:

多嚢胞性卵巣症候群周産期合併症妊婦リスク評価予防戦略

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