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Updated: Jan 21, 2026

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Canine Intestinal Organoids in a Dual-Chamber Permeable Support System
Published on: March 2, 2022
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心房室同期は、デュアルチャンバー無リードペースメーカーにより、実世界条件下で維持される
Pascal Defaye1, Vivek Y Reddy2, James E Ip3
1CHRU Grenoble Alpes, Grenoble, France.
まとめ
デュアルチャンバー無リードペースメーカーは、日常活動中に96%以上の心房室同期を達成しました。これは、システムが
科学分野:
- 心臓病学;生体医工学;医療機器
背景:
- デュアルチャンバー無リードペースメーカー(LP)システムは、心房および心室のデバイス協調のために、ワイヤレス implant-to-implant (i2iTM) 通信を利用します。;ペースメーカーの性能を実世界条件下で評価するためには、日常生活中の心房室同期を評価することが重要です。
研究 の 目的:
- 24時間の歩行期間中のデュアルチャンバー無リードペースメーカー(LP)システムの心房室(AV)同期を評価すること。;標準的なペーシング適応を有する患者におけるデュアルチャンバーLPの安全性と性能を評価すること。
主な方法:
- デュアルチャンバーペーシングを必要とする患者を対象とした、前向き、単腕、多施設共同臨床試験(NCT05252702)が実施されました。;患者は、日常生活を再開しながら、ホルターデバイスを用いた24時間の歩行モニタリングを受けました。;独立したコアラボ分析により、ペーシングおよびセンシングされた心房室遅延パラメータに基づいて、同期ビートの割合が裁定されました。
主要な成果:
- 平均心房室同期は96.7%のビートで達成され、心房から心室への伝達成功率(93.4%)および心室から心房への伝達成功率(92.1%)を上回りました。;心房室同期は、歩行可能な環境における様々な心拍数およびペーシング/センシング構成全体で90%以上に一貫して維持されました。;洞房結節機能不全および房室ブロックを有する患者間では、心房室同期に有意な差は観察されませんでした。
結論:
- デュアルチャンバー無リードペーシングシステムは、日常生活の24時間の期間にわたって高い全体的な心房室同期(>96%)を示しました。;これは、実世界での歩行条件下で真のデュアルチャンバーDDD(R)ペーシングを維持する能力を確認します。;このシステムは、高度なペーシングサポートを必要とする患者にとって有望な性能を示しています。
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