甲状腺ホルモン感受性指標と地域在住甲状腺機能正常高齢者の腎機能との関連：横断研究
Junzhe Xie1, Chunlian Zhang2, Jifeng Fan2
1Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Scientific reports
|January 19, 2026
まとめ
中心性甲状腺ホルモン感受性指標（TSHI、TT4RIを含む）は、甲状腺機能正常高齢者における腎機能低下と関連していた。これらの所見は、加齢集団における甲状腺調節と腎臓の健康との潜在的な関連性を強調している。
科学分野:
- 内分泌学
- 腎臓病学
- 老年医学
背景:
- 甲状腺ホルモン感受性指標（TFQI、TSHI、TT4RI）は、中心性の甲状腺ホルモン調節を評価する。
- これらの指標と甲状腺機能正常高齢者の腎機能との関連は不明なままである。
研究 の 目的:
- 地域在住の甲状腺機能正常高齢者における中心性甲状腺ホルモン感受性指標と腎機能（eGFR）との関連を調査すること。
主な方法:
- 上海の地域在住甲状腺機能正常成人（65歳以上）2,027人を対象とした横断研究。
- TFQI、TSHI、TT4RIを算出し、MDRD式を用いてeGFRを測定した。
- 多変量回帰分析および制限立方スプライン分析を用いて関連を検討した。
主要な成果:
- 腎機能低下の有病率は15.9%であった。
- 3つの指標すべてが、腎機能低下のある参加者で高値であった。
- TSHIおよびTT4RIは、調整後、eGFRおよび腎機能低下との有意な逆関連を示した。
結論:
- 中心性甲状腺ホルモン感受性指標、特にTSHIおよびTT4RIは、甲状腺機能正常高齢者における腎機能低下と独立して関連していた。
- これらの所見は、高齢者における甲状腺調節と腎臓の健康との関連を示唆している。
関連する概念動画
01:18Functions of Thyroid Hormones
5.0K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
5.0K
01:50Cross-Sectional Research
12.4K
In cross-sectional research, a researcher compares multiple segments of the population at the same time. If they were interested in people's dietary habits, the researcher might directly compare different groups of people by age. Instead of following a group of people for 20 years to see how their dietary habits changed from decade to decade, the researcher would study a group of 20-year-old individuals and compare them to a group of 30-year-old individuals and a group of 40-year-old...
12.4K
01:20Synthesis and Regulation of Thyroid Hormones
7.3K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
7.3K
01:33Hormonal Regulation
35.8K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
35.8K
01:24Serum Studies: Renal Function Tests
371
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
371
01:26Profile Leveling and Cross Sections
1.6K
Profile leveling and cross-sections are surveying methods used to determine and document terrain elevations for infrastructure projects such as highways, railroads, canals, and pipelines. These methods provide data for earthwork planning and alignment of proposed routes. Profile leveling involves measuring elevations along a fixed line to create a vertical terrain profile. A surveyor sets up a leveling instrument at the benchmark (BM) and records a backsight (BS) to determine the...
1.6K