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Updated: Jan 21, 2026

The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes

The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes

Published on: April 10, 2015

NIR照射による近赤外線媒介の相乗的な癌治療のための銅ペルオキシドおよびルテニウム錯体を組み込んだPt(IV)プロドラッグゲーティングMOF

Romaine Parker¹, Rajeshkumar Anbazhagan¹, Chia-Yu Kuo¹

¹Institute of Clinical Pharmacy and Pharmaceutical Sciences, School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan City 70101, Taiwan. thchen@gs.ncku.edu.tw.

Biomaterials science

|January 20, 2026

Abstract:

The development of efficient and multifunctional nanosystems is crucial for enhancing anticancer therapy. The incorporation of therapeutic agents in nanocarriers often results in premature drug release, leading to unsatisfactory therapeutic effects. To overcome these challenges, a nanosystem, MOF@Cu/Ru/Pt (MOF = metal-organic framework UiO-67(bpy), bpy = bipyridine, Cu = copper peroxide, Ru = [Ru(bpy)₃]²⁺, and Pt = Pt(IV) prodrug), is synthesized. The chemotherapeutic Pt(IV) prodrug can coordinate with the MOF and act as a gating agent for the confinement and the glutathione-responsive controlled release of Cu and Ru species, respectively, for chemodynamic/photothermal and photodynamic therapies. Upon exposure to near-infrared irradiation, this material facilitates the enhanced generation of reactive oxygen species and a temperature rise. The in vitro studies of MOF@Cu/Ru/Pt demonstrate excellent biocompatibility in normal cells and remarkable therapeutic efficacy in 4T1 cancer cells, attributed to the synergistic anticancer effects.

キーワード:

癌治療ナノシステム薬物放出相乗効果生体適合性

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Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs

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