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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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血管内治療のための磁気誘導型、刺激応答型マイクロデバイス

Sanjay Manoharan1, Vivek Subramanian2

  • 1Laboratory for Advanced Fabrication Technologies, Institute of Electrical and Micro Engineering, École Polytechnique Fédérale de Lausanne (EPFL), Neuchâtel, 2000, Switzerland. sanjay.manoharan@epfl.ch.

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まとめ

本研究では、磁気誘導と近赤外光による遠隔展開を用いた動脈瘤治療用のワイヤレス血管内マイクロデバイスを発表する。この新しいプラットフォームは、困難な解剖学的構造へのアクセスを改善し、治療選択肢を向上させる。

キーワード:
動脈瘤血管内デバイス血流遮断磁気駆動マイクロロボット刺激応答性材料

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科学分野:

  • 生体医工学;医療機器;材料科学

背景:

  • カテーテルベースのシステムは、複雑な血管解剖学的構造における血管内治療へのアクセスを制限します。;動脈瘤修復のための高度で低侵襲な治療戦略の必要性が存在します。

研究 の 目的:

  • ワイヤレス動脈瘤治療のためのテザーレスマイクロデバイスプラットフォームを開発および検証すること。;血管内デバイスの磁気誘導と近赤外線（NIR）トリガー展開を実証すること。;動脈瘤内血流を低減するプラットフォームの有効性を評価すること。

主な方法:

  • 磁気誘導とNIRトリガー形状記憶ポリマー（SMP）展開を組み合わせたマイクロデバイスプラットフォームを設計しました。;2つのデバイスアーキテクチャ（血流遮断器、閉塞器）を設計し、血管ファントムでテストしました。;流体応答性、磁気変調型スティックスリップ（F-MMSS）フレームワークを使用してナビゲーションをモデル化しました。;磁気ステアリング、NIR展開、および血行動態効果を実験的に評価しました。

主要な成果:

  • 現実的な血管ファントムにおいて、マイクロデバイスのワイヤレスナビゲーションと遠隔展開に成功しました。;NIR活性化により、生体外組織を介した非侵襲的な展開が可能になりました。;Particle Image VelocimetryおよびCFDにより、動脈瘤内の速度の大幅な低下が確認されました。;PLA-メラニン複合材料は、予備的な生体適合性と血液適合性を示しました。

結論:

  • 開発されたプラットフォームは、血管内マイクロデバイスのワイヤレスナビゲーションと遠隔展開の概念実証を提供します。;この技術は、動脈瘤修復のためのカテーテルベースの治療に代わる有望な選択肢を提供します。;この技術を臨床応用するには、さらなるin vivo評価が必要です。