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Updated: Jan 22, 2026

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine

Published on: February 16, 2018

セロシアフリンおよび類似体の提案構造の合成：逐次カスケード環拡大反応を利用

Jerry K F Tam¹, Lachlan J N Waddell¹, Kleopas Y Palate¹

¹University of York, Department of Chemistry, Heslington, York YO10 5DD, U.K.

Organic letters

|January 21, 2026

Abstract:

The first synthesis of the proposed structure of spermidine derived macrocyclic alkaloid celacarfurine is described. A versatile synthetic strategy has been developed based on sequential cascade ring expansion reactions, with high dilution conditions not needed for any of the steps. The same general strategy was also used to generate a series of macrocyclic analogues. The physical properties and spectroscopic data obtained for our synthetic product do not match those reported for the isolated alkaloid.

キーワード:

セロシアフリン大環状アルカロイド環拡大反応全合成有機合成化学

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Published on: February 17, 2017

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